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Laboratorium yang terletak pada lantai basement Gedung Pascasarjana Tahir Foundation sayap utara ini berfungsi mendukung kegiatan penelitian dan pengembangan terkait sistem informasi kesehatan. Beberapa aktivitasnya termasuk pemanfaatan Health Management Information System dan pengembangan SIMPUS, SIMRS serta SIMKlinik. Laboratorium ini juga digunakan untuk aktivitas pembelajaran mahasiswa seperti magang maupun capstone/tugas akhir. Berbagai kolaborasi mahasiswa dan dosen juga dikembangkan di laboratorium ini dengan memanfaatkan hibah/pendanaan eksternal seperti kegiatan pengembangan sistem informasi eZoonosis bersama Kementerian Kesehatan, uji coba skema pembiayaan telemedicine bersama Kementerian Kesehatan dan BPJS Kesehatan, evaluasi digitalisasi kesehatan ibu dan anak bersama Bappenas, pengembangan aplikasi ASPAK bersama Kementerian Kesehatan dan WHO, dan lain-lain. Laboratorium ini juga sedang dikembangkan untuk interoperabilitas sistem informasi menggunakan standar Fast Healthcare Interoperability Resources (FHIR).
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